Cyclosporine immunosuppression and delayed graft function in 455 cadaveric renal transplants.

نویسندگان

  • R J Taylor
  • M D Landreneau
  • L Makowka
  • T J Rosenthal
  • R D Gordon
  • A G Tzakis
  • T E Starzl
  • T R Hakala
چکیده

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Long-term results of cyclosporine-steroid therapy in 131 non-matched cadaveric renal transplants.

One-hundred-and-twenty-eight recipients of 131 consecutive, non-matched cadaver renal allografts were treated with cyclosporine and steroids. They have been followed for 4 to 6 yr. Cumulative patient survival at 1-yr was 92.2% and at 6yr it is 77.8%. Cumulative graft survival at 1-yr was 79.4% and at 6 yr it is 50.0%. After the high-risk 1st yr, the rate of graft loss was even and similar to th...

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Second cadaver kidney transplants: improved graft survival in secondary kidney transplants using cyclosporin A.

A total of 42 patients who had failed prior renal transplantation underwent repeat cadaveric transplantation using cyclosporin A and low dose steroid immunosuppression. Patient survival at 1 year was 100 per cent. Over-all graft survival was 83 per cent at 1 year, which was significantly better than had been obtainable previously in this high risk group. Repeat cadaver transplantation with cycl...

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Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy.

In the past 15 years, short-term success rates for allografts of kidney, heart, liver, and kidney/pancreas have reached unprecedented levels largely due to cyclosporine-based immunosuppressive regimens. Most transplant centers around the world achieve 85 to 90% one-year graft survival for kidney transplants and very few patients suffer loss of life because of modern medical management [1, 2]. T...

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The impact of triple drug immunosuppression on clinical results of cadaveric kidney transplantation: a comparison of conventional immunosuppression.

A retrospective study was carried out in 110 cadaveric kidney transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (AZP) and steroids (triple-drug therapy) with those of higher doses of steroids plus AZP (conventional immunosuppression). Graft survival rate in the triple-drug therapy was 77%, 69%, and 69% at 1, 3, and 5 years, respectively. This was sign...

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Cadaveric donor factor variations during a 12-year period: influence on kidney transplant outcomes.

UNLABELLED Our purpose was to evaluate changes in cadaveric donor factors between 1993 and 2004 and their impact on the short- and long-term outcomes of renal transplants in a single center. PATIENTS AND METHODS Cadaveric renal transplants performed in our unit between 1993 and 2004 were divided in two groups of identical length: A (n = 455; 1993-1998) and B (n = 465; 1999-2004). Major differ...

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عنوان ژورنال:
  • Transplantation proceedings

دوره 19 1 Pt 3  شماره 

صفحات  -

تاریخ انتشار 1987